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San Isidro Campus, the eldest of the six campuses, is situated in a 55-hectare lot in San Isidro Nueva Ecija. It is only an hour travel away from the busy City of San Fernando in Pampanga. The Campus offers Bachelor of Secondary Education, Bachelor of Science in Industrial Education, Bachelor of Elementary Education, Bachelor of Science in Information and Communications Technology, Bachelor of Science in Business Administration, Accelerated Vocational Training Program, and the Science and Technology Secondary School Curriculum.
Report by Rovic Bautista 
Honoring and preserving Novo Ecijano heritage, the Nueva Ecija University of Science and Technology–San Isidro Campus (NEUST-SIC) joined the province in commemorating the 129th First Cry of Nueva Ecija at the San Isidro Town Plaza today. Students from SIC showcased cultural dances and performed a song alongside various institutions from the municipality of San Isidro.
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Report by Hanz Jefferson Medalla 
Bilang bahagi ng pagdiriwang sa seremonya ng pagtatapos, ginanap ang misa ng pasasalamat ng Nueva Ecija University of Science and Technology - San Isidro Campus (NEUST-SIC) na may temang "NEUST: Expanding Horizons, towards Global Excellence in Higher Education" sa St. Isidore the Farmer Parish, San Isidro Nueva Ecija ngayong umaga. Pinangunahan ang misa ni Rev. Fr. Edilberto Dela Rosa Jr., kura paroko ng nasabing parokya.
Sa kanyang homiliya, ibinahagi niya ang isang mensahe na nagbibigay-diin sa kahalagahan ng pagiging masunurin.
"Sa paglalakbay natin, yung mga masunurin, sila talaga ang may nararating sa buhay—kung sumunod kayo sa mga magulang ninyo, narating ninyo ang oras na ito; nang sumunod kayo sa mga guro ninyo, narating ninyo ang oras na ito...
Report by Jewel Garcia 
Mrs. Jamie A. Castro, a faculty member of NEUST - San Isidro Campus (NEUST- SIC), served as the Filipino presenter at the Persidangan Angtarabangsa Psikologi Gunaan Dan Pedagogi 2025 (International Conference on Applied Psychology and Pedagogy - ICAPP) 2025, held on June 16 -17 in Bandar Seri Begawan, Brunei Darussalam.
Organized by the Kolej Universiti Perguruan Ugama Seri Begawan (KUPU SB), in collaboration with the Ministry of Religious Affairs and the Association of Southeast Asian Teacher Education Network (AsTEN), the two-day regional gathering brought together educators and mental health professionals across Southeast Asia to share research and practices that advance psychological and pedagogical development in the region.
Report by Kevin Justine Sta. Maria | Bryan Soriano 
Celebrating academic milestone, the NEUST-San Isidro Campus (NEUST-SIC) held its 10th Recognition and Moving-Up Ceremony with the theme “Henerasyon ng Pagkakaisa: Kaagapay sa Bagong Pilipinas” at NEUST-SIC campus gymnasium today.
A total of 153 academic awardees from different departments, 36 junior high school completers, and 20 non-academic awardees gathered at the said event.
Dr. Neddie L. Balagtas-Daquiz, the guest speaker, shared her message about one person making a difference in a community, as she emphasized the power it holds to influence others.
Report by Maureen Villadon 
In celebration of the 10th Recognition and Junior High School Moving-Up Ceremony, Laboratory High School (LHS) students, together with their parents, faculty, and staff, gathered for a Thanksgiving Mass at St. Isidore the Farmer Parish in San Isidro, Nueva Ecija this morning.
Rev. Fr. Edilberto Dela Rosa Jr. presided over the Mass. In his homily, he shared a message emphasizing the value of prayer.
“Ang panalangin ay pagkilala sa Diyos at ang panalangin ay pagkilala sa Ama patungo sa Diyos... ang panalangin ay hindi lamang sa sarili, ito ay para kapwa din,” Fr. Dela Rosa said.
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